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Ephrin-As and neural activity are required for eye-specific patterning during retinogeniculate mapping.


ABSTRACT: In mammals, retinal ganglion cell (RGC) projections initially intermingle and then segregate into a stereotyped pattern of eye-specific layers in the dorsal lateral geniculate nucleus (dLGN). Here we found that in mice deficient for ephrin-A2, ephrin-A3 and ephrin-A5, eye-specific inputs segregated but the shape and location of eye-specific layers were profoundly disrupted. In contrast, mice that lacked correlated retinal activity did not segregate eye-specific inputs. Inhibition of correlated neural activity in ephrin mutants led to overlapping retinal projections that were located in inappropriate regions of the dLGN. Thus, ephrin-As and neural activity act together to control patterning of eye-specific retinogeniculate layers.

SUBMITTER: Pfeiffenberger C 

PROVIDER: S-EPMC1352169 | biostudies-literature | 2005 Aug

REPOSITORIES: biostudies-literature

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Ephrin-As and neural activity are required for eye-specific patterning during retinogeniculate mapping.

Pfeiffenberger Cory C   Cutforth Tyler T   Woods Georgia G   Yamada Jena J   Rentería René C RC   Copenhagen David R DR   Flanagan John G JG   Feldheim David A DA  

Nature neuroscience 20050717 8


In mammals, retinal ganglion cell (RGC) projections initially intermingle and then segregate into a stereotyped pattern of eye-specific layers in the dorsal lateral geniculate nucleus (dLGN). Here we found that in mice deficient for ephrin-A2, ephrin-A3 and ephrin-A5, eye-specific inputs segregated but the shape and location of eye-specific layers were profoundly disrupted. In contrast, mice that lacked correlated retinal activity did not segregate eye-specific inputs. Inhibition of correlated n  ...[more]

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