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ZntB is a novel Zn2+ transporter in Salmonella enterica serovar Typhimurium.

ABSTRACT: A Zn2+ transport system encoded by the zntB locus of Salmonella enterica serovar Typhimurium has been identified. The protein encoded by this locus is homologous to the CorA family of Mg2+ transport proteins and is widely distributed among the eubacteria. Mutations at zntB confer an increased sensitivity to the cytotoxic effects of Zn2+ and Cd2+, a phenotype that suggests that the encoded protein mediates the efflux of both cations. A direct analysis of transport activity identified a capacity for Zn2+ efflux. These data identify ZntB as a zinc efflux pathway in the enteric bacteria and assign a new function to the CorA family of cation transporters.

SUBMITTER: Worlock AJ

PROVIDER: S-EPMC135258 | biostudies-literature | 2002 Aug

REPOSITORIES: biostudies-literature

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ZntB is a novel Zn2+ transporter in Salmonella enterica serovar Typhimurium.

Worlock Ashley J AJ Smith Ronald L RL

Journal of bacteriology 20020801 16

A Zn2+ transport system encoded by the zntB locus of Salmonella enterica serovar Typhimurium has been identified. The protein encoded by this locus is homologous to the CorA family of Mg2+ transport proteins and is widely distributed among the eubacteria. Mutations at zntB confer an increased sensitivity to the cytotoxic effects of Zn2+ and Cd2+, a phenotype that suggests that the encoded protein mediates the efflux of both cations. A direct analysis of transport activity identified a capacity f ...[more]

PMID: 12142406

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