Urocortin-deficient mice display normal stress-induced anxiety behavior and autonomic control but an impaired acoustic startle response.
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ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC135620 | biostudies-literature | 2002 Sep
REPOSITORIES: biostudies-literature
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Urocortin-deficient mice display normal stress-induced anxiety behavior and autonomic control but an impaired acoustic startle response.
Wang Xiaozhong X Su Hong H Copenhagen Leslie D LD Vaishnav Sukishi S Pieri Fredalina F Shope Cynthia Do CD Brownell William E WE De Biasi Mariella M Paylor Richard R Bradley Allan A
Molecular and cellular biology 20020901 18
Corticotropin-releasing hormone (Crh) plays an important role in modulating physiological and behavioral responses to stress. Its actions are mediated through two receptors, Crhr1 and Crhr2. Urocortin (Ucn), a Crh-related neuropeptide and the postulated endogenous ligand for Crhr2, is a potential mediator of stress responses. We generated Ucn-deficient mice using embryonic stem cell technology to determine its role in stress-induced behavioral and autonomic responses. Unlike Crhr1- or Crhr2-defi ...[more]
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