Ontology highlight
ABSTRACT:
SUBMITTER: Deng J
PROVIDER: S-EPMC1356302 | biostudies-literature | 2005 Dec
REPOSITORIES: biostudies-literature
Deng Junpeng J Ernst Nancy Lewis NL Turley Stewart S Stuart Kenneth D KD Hol Wim G J WG
The EMBO journal 20051110 23
Trypanosomatids are pathogenic protozoa that undergo a unique form of post-transcriptional RNA editing that inserts or deletes uridine nucleotides in many mitochondrial pre-mRNAs. Editing is catalyzed by a large multiprotein complex, the editosome. A key editosome enzyme, RNA editing terminal uridylyl transferase 2 (TUTase 2; RET2) catalyzes the uridylate addition reaction. Here, we report the 1.8 A crystal structure of the Trypanosoma brucei RET2 apoenzyme and its complexes with uridine nucleot ...[more]