Ontology highlight
ABSTRACT:
SUBMITTER: Chow EK
PROVIDER: S-EPMC1356307 | biostudies-literature | 2005 Dec
REPOSITORIES: biostudies-literature
Chow Edward K EK O'connell Ryan M RM Schilling Stephen S Wang Xiao-Fan XF Fu Xin-Yuan XY Cheng Genhong G
The EMBO journal 20051124 23
Transforming growth factor-beta (TGF-beta) and type I interferon (IFN) autocrine/paracrine loops are recognized as key mediators of signaling cascades that control a variety of cellular functions. Here, we describe a novel mechanism by which Toll-like receptor (TLR) agonists utilize these two autocrine/paracrine loops to differentially regulate the induction of PDGF-B, a growth factor implicated in a number of diseases ranging from tumor metastasis to glomerulonephritis. We demonstrate that CpG- ...[more]