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Role of phase variation of type 1 fimbriae in a uropathogenic Escherichia coli cystitis isolate during urinary tract infection.


ABSTRACT: Type 1 fimbrial phase-locked mutants of uropathogenic Escherichia coli cystitis isolate F11 were used to assess the role of the invertible element during urinary tract infection. Compared to the wild type, the phase-locked off mutant was attenuated, and constitutive production of type 1 fimbriae by the phase-locked on mutant did not provide a competitive advantage.

SUBMITTER: Snyder JA 

PROVIDER: S-EPMC1360342 | biostudies-literature | 2006 Feb

REPOSITORIES: biostudies-literature

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Role of phase variation of type 1 fimbriae in a uropathogenic Escherichia coli cystitis isolate during urinary tract infection.

Snyder Jennifer A JA   Lloyd Amanda L AL   Lockatell C Virginia CV   Johnson David E DE   Mobley Harry L T HL  

Infection and immunity 20060201 2


Type 1 fimbrial phase-locked mutants of uropathogenic Escherichia coli cystitis isolate F11 were used to assess the role of the invertible element during urinary tract infection. Compared to the wild type, the phase-locked off mutant was attenuated, and constitutive production of type 1 fimbriae by the phase-locked on mutant did not provide a competitive advantage. ...[more]

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