Ontology highlight
ABSTRACT:
SUBMITTER: Villa R
PROVIDER: S-EPMC1360559 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
Villa Raffaella R Morey Lluis L Raker Veronica A VA Buschbeck Marcus M Gutierrez Arantxa A De Santis Francesca F Corsaro Massimo M Varas Florencio F Bossi Daniela D Minucci Saverio S Pelicci Pier Giuseppe PG Di Croce Luciano L
Proceedings of the National Academy of Sciences of the United States of America 20060123 5
PML-RARalpha induces a block of hematopoietic differentiation and acute promyelocytic leukemia. This block is based on its capacity to inactivate target genes by recruiting histone deacetylase (HDAC) and DNA methyltransferase activities. Here we report that MBD1, a member of a conserved family of proteins able to bind methylated DNA, cooperates with PML-RARalpha in transcriptional repression and cellular transformation. PML-RARalpha recruits MBD1 to its target promoter through an HDAC3-mediated ...[more]