Ontology highlight
ABSTRACT:
SUBMITTER: Popova B
PROVIDER: S-EPMC1360742 | biostudies-literature | 2006
REPOSITORIES: biostudies-literature
Popova Blagovesta B Kuhlmann Markus M Hinas Andrea A Söderbom Fredrik F Nellen Wolfgang W
Nucleic acids research 20060202 3
We have identified a putative RNA helicase from Dictyostelium that is closely related to drh-1, the 'dicer-related-helicase' from Caenorhabditis elegans and that also has significant similarity to proteins from vertebrates and plants. Green fluorescent protein (GFP)-tagged HelF protein was localized in speckles in the nucleus. Disruption of the helF gene resulted in a mutant morphology in late development. When transformed with RNAi constructs, HelF- cells displayed enhanced RNA interference on ...[more]