Ontology highlight
ABSTRACT:
SUBMITTER: Richards RJ
PROVIDER: S-EPMC1360744 | biostudies-literature | 2006
REPOSITORIES: biostudies-literature
Richards Rebecca J RJ Theimer Carla A CA Finger L David LD Feigon Juli J
Nucleic acids research 20060201 3
Telomere addition by telomerase requires an internal templating sequence located in the RNA subunit of telomerase. The correct boundary definition of this template sequence is essential for the proper addition of the nucleotide repeats. Incorporation of incorrect telomeric repeats onto the ends of chromosomes has been shown to induce chromosomal instability in ciliate, yeast and human cells. A 5' template boundary defining element (TBE) has been identified in human, yeast and ciliate telomerase ...[more]