Ontology highlight
ABSTRACT:
SUBMITTER: Gotz R
PROVIDER: S-EPMC1361767 | biostudies-literature | 2005 Sep
REPOSITORIES: biostudies-literature
Götz Rudolf R Wiese Stefan S Takayama Shinichi S Camarero Guadalupe C GC Rossoll Wilfried W Schweizer Ulrich U Troppmair Jakob J Jablonka Sibylle S Holtmann Bettina B Reed John C JC Rapp Ulf R UR Sendtner Michael M
Nature neuroscience 20050821 9
Bag1 is a cochaperone for the heat-shock protein Hsp70 that interacts with C-Raf, B-Raf, Akt, Bcl-2, steroid hormone receptors and other proteins. Here we use targeted gene disruption in mice to show that Bag1 has an essential role in the survival of differentiating neurons and hematopoietic cells. Cells of the fetal liver and developing nervous system in Bag1-/- mice underwent massive apoptosis. Lack of Bag1 did not disturb the primary function of Akt or Raf, as phosphorylation of the forkhead ...[more]