Ontology highlight
ABSTRACT:
SUBMITTER: Addison WR
PROVIDER: S-EPMC136192 | biostudies-literature | 2002 Jun
REPOSITORIES: biostudies-literature
Addison William R WR Walters Kathie-Anne KA Wong Winnie W S WW Wilson John S JS Madej Danuta D Jewell Lawrence D LD Tyrrell D Lorne J DL
Journal of virology 20020601 12
Covalently closed circular DNA (cccDNA) is a crucial intermediate in the replication of hepadnaviruses. We inhibited the replication of duck hepatitis B virus in congenitally infected ducks with a combination of lamivudine and a dideoxyguanosine prodrug. Inhibition of viral replication should prevent renewal of the cccDNA pool, and its decay was measured in liver biopsy samples collected over a 5-month period. In three ducks, the cccDNA pools declined exponentially, with half-lives ranging from ...[more]