Ontology highlight
ABSTRACT:
SUBMITTER: Gregorevic P
PROVIDER: S-EPMC1365046 | biostudies-literature | 2004 Aug
REPOSITORIES: biostudies-literature
Nature medicine 20040725 8
A major obstacle limiting gene therapy for diseases of the heart and skeletal muscles is an inability to deliver genes systemically to muscles of an adult organism. Systemic gene transfer to striated muscles is hampered by the vascular endothelium, which represents a barrier to distribution of vectors via the circulation. Here we show the first evidence of widespread transduction of both cardiac and skeletal muscles in an adult mammal, after a single intravenous administration of recombinant ade ...[more]