Ontology highlight
ABSTRACT:
SUBMITTER: Goncalves MA
PROVIDER: S-EPMC136621 | biostudies-literature | 2002 Nov
REPOSITORIES: biostudies-literature
Gonçalves Manuel A F V MA van der Velde Ietje I Janssen Josephine M JM Maassen Bram T H BT Heemskerk Evert H EH Opstelten Dirk-Jan E DJ Knaän-Shanzer Shoshan S Valerio Dinko D de Vries Antoine A F AA
Journal of virology 20021101 21
Effective gene therapy is dependent on safe gene delivery vehicles that can achieve efficient transduction and sustained transgene expression. We are developing a hybrid viral vector system that combines in a single particle the large cloning capacity and efficient cell cycle-independent nuclear gene delivery of adenovirus (Ad) vectors with the long-term transgene expression and lack of viral genes of adeno-associated virus (AAV) vectors. The strategy being pursued relies on coupling the AAV DNA ...[more]