Ontology highlight
ABSTRACT:
SUBMITTER: Gaudray G
PROVIDER: S-EPMC136662 | biostudies-literature | 2002 Dec
REPOSITORIES: biostudies-literature
Gaudray Gilles G Gachon Frederic F Basbous Jihane J Biard-Piechaczyk Martine M Devaux Christian C Mesnard Jean-Michel JM
Journal of virology 20021201 24
The RNA genome of the human T-cell leukemia virus type 1 (HTLV-1) codes for proteins involved in infectivity, replication, and transformation. We report in this study the characterization of a novel viral protein encoded by the complementary strand of the HTLV-1 RNA genome. This protein, designated HBZ (for HTLV-1 bZIP factor), contains a N-terminal transcriptional activation domain and a leucine zipper motif in its C terminus. We show here that HBZ is able to interact with the bZIP transcriptio ...[more]