Ontology highlight
ABSTRACT:
SUBMITTER: Buceta J
PROVIDER: S-EPMC1366723 | biostudies-literature | 2005 Oct
REPOSITORIES: biostudies-literature
Buceta Javier J Ibañes Marta M Rasskin-Gutman Diego D Okada Yasushi Y Hirokawa Nobutaka N Izpisúa-Belmonte Juan Carlos JC
Biophysical journal 20050722 4
Nodal cilia dynamics is a key factor for left/right axis determination in mouse embryos through the induction of a leftward fluid flow. So far it has not been clearly established how such dynamics is able to induce the asymmetric leftward flow within the node. Herein we propose that an asymmetric two-phase nonplanar beating cilia dynamics that involves the bending of the ciliar axoneme is responsible for the leftward fluid flow. We support our proposal with a host of hydrodynamic arguments, in s ...[more]