Ontology highlight
ABSTRACT:
SUBMITTER: Myers EL
PROVIDER: S-EPMC136738 | biostudies-literature | 2002 Nov
REPOSITORIES: biostudies-literature
Myers Erin L EL Allen Jane F JF
Journal of virology 20021101 22
The final stages of budding and release of a retroviral particle from the cell require the late (L) domain of Gag. Recently, ubiquitin and ubiquitin ligases have been implicated in the late stages of retroviral budding. In a yeast two-hybrid screen of a T-cell cDNA library to identify cellular proteins that interact with human immunodeficiency virus type 2 (HIV-2) Gag polyprotein, we identified Tsg101, an inactive homologue of ubiquitin ligase E2. Tsg101 and HIV-2 Gag interact specifically in vi ...[more]