E2F1 is crucial for E2F-dependent apoptosis.
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ABSTRACT:
SUBMITTER: Lazzerini Denchi E
PROVIDER: S-EPMC1369111 | biostudies-literature | 2005 Jul
REPOSITORIES: biostudies-literature
Publications
E2F1 is crucial for E2F-dependent apoptosis.
Lazzerini Denchi Eros E Helin Kristian K
EMBO reports 20050701 7
Loss of the retinoblastoma protein, pRB, leads to apoptosis, and several results have suggested that this is dependent on the E2F transcription factors. However, so far, the ability of the different E2F family members to contribute to apoptosis is controversial. Here, we show that ectopic expression of E2F3 results in apoptosis in both primary mouse fibroblasts and transgenic mice. Apoptosis induced by E2F3 is associated with the accumulation of E2F1 and, strikingly, we found that E2F3-induced a ...[more]
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