Anopheles gambiae SRPN2 facilitates midgut invasion by the malaria parasite Plasmodium berghei.
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ABSTRACT:
SUBMITTER: Michel K
PROVIDER: S-EPMC1369158 | biostudies-literature | 2005 Sep
REPOSITORIES: biostudies-literature
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Anopheles gambiae SRPN2 facilitates midgut invasion by the malaria parasite Plasmodium berghei.
Michel Kristin K Budd Aidan A Pinto Sofia S Gibson Toby J TJ Kafatos Fotis C FC
EMBO reports 20050901 9
We report on a phylogenetic and functional analysis of genes encoding three mosquito serpins (SRPN1, SRPN2 and SRPN3), which resemble known inhibitors of prophenoloxidase-activating enzymes in other insects. Following RNA interference induction by double-stranded RNA injection, knockdown of SRPN2 in adult Anopheles gambiae produced a notable phenotype: the appearance of melanotic pseudotumours, which increased in size and number with time, indicating spontaneous melanization and association with ...[more]
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