Ontology highlight
ABSTRACT:
SUBMITTER: Goodfellow I
PROVIDER: S-EPMC1369186 | biostudies-literature | 2005 Oct
REPOSITORIES: biostudies-literature
Goodfellow Ian I Chaudhry Yasmin Y Gioldasi Ioanna I Gerondopoulos Andreas A Natoni Alessandro A Labrie Louisette L Laliberté Jean-François JF Roberts Lisa L
EMBO reports 20051001 10
Unlike other positive-stranded RNA viruses that use either a 5'-cap structure or an internal ribosome entry site to direct translation of their messenger RNA, calicivirus translation is dependent on the presence of a protein covalently linked to the 5' end of the viral genome (VPg). We have shown a direct interaction of the calicivirus VPg with the cap-binding protein eIF 4 E. This interaction is required for calicivirus mRNA translation, as sequestration of eIF 4 E by 4 E-BP 1 inhibits translat ...[more]