Ontology highlight
ABSTRACT:
SUBMITTER: Stenqvist A
PROVIDER: S-EPMC1369188 | biostudies-literature | 2005 Oct
REPOSITORIES: biostudies-literature
Stenqvist Anna A Agerman Karin K Marmigère Frédéric F Minichiello Liliana L Ernfors Patrik P
EMBO reports 20051001 10
Neurotrophins control neuronal survival in a target-derived manner during the period of naturally occurring cell death in development. The specificity of this mechanism has been attributed to a restricted spatio-temporal expression of neurotrophin ligands in target tissues, as well as a selective expression of their cognate tyrosine kinase (Trk) receptors in different neuronal subpopulations. However, several in vitro and in vivo studies of null mutant mice have suggested that neurotrophin 3 (NT ...[more]