Ontology highlight
ABSTRACT:
SUBMITTER: Hill JM
PROVIDER: S-EPMC136945 | biostudies-literature | 2002 Dec
REPOSITORIES: biostudies-literature
The EMBO journal 20021201 23
PEA-15 is a multifunctional protein that modulates signaling pathways which control cell proliferation and cell death. In particular, PEA-15 regulates the actions of the ERK MAP kinase cascade by binding to ERK and altering its subcellular localization. The three-dimensional structure of PEA-15 has been determined using NMR spectroscopy and its interaction with ERK defined by characterization of mutants that modulate ERK function. PEA-15 is composed of an N-terminal death effector domain (DED) a ...[more]