Ontology highlight
ABSTRACT:
SUBMITTER: Souopgui J
PROVIDER: S-EPMC136948 | biostudies-literature | 2002 Dec
REPOSITORIES: biostudies-literature
Souopgui Jacob J Sölter Marion M Pieler Tomas T
The EMBO journal 20021201 23
We have isolated the Xenopus p21-activated kinase 3 (XPak3) by virtue of its expression in the territory of primary neurogenesis in the developing embryo. XPak3, but not the other Pak variants, responds positively to X-Ngnr-1 and negatively to X-Notch-1. A constitutively active form of XPak3, generated by fusing a myristylation signal to the N-terminus (XPak3-myr), induces early cell cycle arrest at high concentrations, while ectopic expression of low amounts induces premature neuronal different ...[more]