Ontology highlight
ABSTRACT:
SUBMITTER: Habu T
PROVIDER: S-EPMC136962 | biostudies-literature | 2002 Dec
REPOSITORIES: biostudies-literature
Habu Toshiyuki T Kim Sang Hoon SH Weinstein Jasminder J Matsumoto Tomohiro T
The EMBO journal 20021201 23
MAD2 is a key component of the spindle checkpoint that delays the onset of anaphase until all the kinetochores are attached to the spindle. It binds to human p55CDC and prevents it from promoting destruction of an anaphase inhibitor, securin. Here we report the characterization of a novel MAD2-binding protein, CMT2. Upon the completion of spindle attachment, formation of the CMT2-MAD2 complex coincides with dissociation of the p55CDC-MAD2 complex. Overexpression of CMT2 in cells arrested by the ...[more]