Identification of VP1/2A and 2C as virulence genes of hepatitis A virus and demonstration of genetic instability of 2C.
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ABSTRACT:
SUBMITTER: Emerson SU
PROVIDER: S-EPMC136972 | biostudies-literature | 2002 Sep
REPOSITORIES: biostudies-literature
Publications
Identification of VP1/2A and 2C as virulence genes of hepatitis A virus and demonstration of genetic instability of 2C.
Emerson Suzanne U SU Huang Ying K YK Nguyen Hanh H Brockington Alicia A Govindarajan Sugantha S St Claire Marisa M Shapiro Max M Purcell Robert H RH
Journal of virology 20020901 17
Fourteen different chimeric virus genomes were constructed from two infectious cDNA clones encoding a virulent and an attenuated isolate, respectively, of the HM175 strain of hepatitis A virus. The ability of each recombinant virus to infect tamarins and to cause acute hepatitis was determined. Comparisons of the genotype and phenotype of each virus suggested that VP1/2A and 2C genes were responsible for virulence. The 2C gene derived from the attenuated parent virus was unstable, and one or mor ...[more]
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