Identification of novel components of Trypanosoma brucei editosomes.
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ABSTRACT:
SUBMITTER: Panigrahi AK
PROVIDER: S-EPMC1370414 | biostudies-literature | 2003 Apr
REPOSITORIES: biostudies-literature
Publications
Identification of novel components of Trypanosoma brucei editosomes.
Panigrahi Aswini K AK Schnaufer Achim A Ernst Nancy L NL Wang Bingbing B Carmean Nicole N Salavati Reza R Stuart Kenneth K
RNA (New York, N.Y.) 20030401 4
The editosome is a multiprotein complex that catalyzes the insertion and deletion of uridylates that occurs during RNA editing in trypanosomatids. We report the identification of nine novel editosome proteins in Trypanosoma brucei. They were identified by mass spectrometric analysis of functional editosomes that were purified by serial ion exchange/gel permeation chromatography, immunoaffinity chromatography specific to the TbMP63 editosome protein, or tandem affinity purification based on a tag ...[more]
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