Ontology highlight
ABSTRACT:
SUBMITTER: Chen CY
PROVIDER: S-EPMC1370557 | biostudies-literature | 2004 Apr
REPOSITORIES: biostudies-literature
Chen Chyi-Ying A CY Xu Nianhua N Zhu Wenmiao W Shyu Ann-Bin AB
RNA (New York, N.Y.) 20040401 4
Many shuttling proteins not only function in the nucleus but also control mRNA fates in the cytoplasm. We test whether a link exists between their nuclear association with mRNPs and their cytoplasmic functions using the p37 isoform of hnRNP D, which inhibits the rapid cytoplasmic mRNA decay in NIH3T3 cells. We showed that p37 shuttles between nucleus and cytoplasm, and narrowed down the nuclear import signal to a 50-amino-acid C-terminal domain. A p37 mutant missing this domain, still capable of ...[more]