Ontology highlight
ABSTRACT:
SUBMITTER: Lingel A
PROVIDER: S-EPMC1370652 | biostudies-literature | 2004 Nov
REPOSITORIES: biostudies-literature
Lingel Andreas A Izaurralde Elisa E
RNA (New York, N.Y.) 20041101 11
RNA interference involves endonucleolytic cleavage of mRNAs at a site determined by complementary siRNAs. Initial cleavage leads to rapid degradation of the message, resulting in a corresponding reduction in the level of the encoded protein. Despite intensive study, the identity of the endonucleolytic activity (designated slicer) has remained obscure. Now, a combination of structural and biochemical analyses provide compelling evidence that human Argonaute2 (Ago2), a protein already known to be ...[more]