Ontology highlight
ABSTRACT:
SUBMITTER: Tiemann-Boege I
PROVIDER: S-EPMC137526 | biostudies-literature | 2002 Nov
REPOSITORIES: biostudies-literature
Tiemann-Boege Irene I Navidi William W Grewal Raji R Cohn Dan D Eskenazi Brenda B Wyrobek Andrew J AJ Arnheim Norman N
Proceedings of the National Academy of Sciences of the United States of America 20021023 23
The lifelong spermatogonial stem cell divisions unique to male germ cell production are thought to contribute to a higher mutation frequency in males. The fact that certain de novo human genetic conditions (e.g., achondroplasia) increase in incidence with the age of the father is consistent with this idea. Although it is assumed that the paternal age effect is the result of an increasing frequency of mutant sperm as a man grows older, no direct molecular measurement of the germ-line mutation fre ...[more]