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Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia.

ABSTRACT: Micro-RNAs (miR genes) are a large family of highly conserved noncoding genes thought to be involved in temporal and tissue-specific gene regulation. MiRs are transcribed as short hairpin precursors ( approximately 70 nt) and are processed into active 21- to 22-nt RNAs by Dicer, a ribonuclease that recognizes target mRNAs via base-pairing interactions. Here we show that miR15 and miR16 are located at chromosome 13q14, a region deleted in more than half of B cell chronic lymphocytic leukemias (B-CLL). Detailed deletion and expression analysis shows that miR15 and miR16 are located within a 30-kb region of loss in CLL, and that both genes are deleted or down-regulated in the majority ( approximately 68%) of CLL cases.

SUBMITTER: Calin GA 

PROVIDER: S-EPMC137750 | biostudies-literature | 2002 Nov

REPOSITORIES: biostudies-literature

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Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia.

Calin George Adrian GA   Dumitru Calin Dan CD   Shimizu Masayoshi M   Bichi Roberta R   Zupo Simona S   Noch Evan E   Aldler Hansjuerg H   Rattan Sashi S   Keating Michael M   Rai Kanti K   Rassenti Laura L   Kipps Thomas T   Negrini Massimo M   Bullrich Florencia F   Croce Carlo M CM  

Proceedings of the National Academy of Sciences of the United States of America 20021114 24

Micro-RNAs (miR genes) are a large family of highly conserved noncoding genes thought to be involved in temporal and tissue-specific gene regulation. MiRs are transcribed as short hairpin precursors ( approximately 70 nt) and are processed into active 21- to 22-nt RNAs by Dicer, a ribonuclease that recognizes target mRNAs via base-pairing interactions. Here we show that miR15 and miR16 are located at chromosome 13q14, a region deleted in more than half of B cell chronic lymphocytic leukemias (B-  ...[more]

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