Ontology highlight
ABSTRACT:
SUBMITTER: Lohmueller KE
PROVIDER: S-EPMC1380210 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
Lohmueller Kirk E KE Mauney Matthew M MM Reich David D Braverman John M JM
American journal of human genetics 20051116 1
Genetic variants that contribute to risk of common disease may differ in frequency across populations more than random variants in the genome do, perhaps because they have been exposed to population-specific natural selection. To assess this hypothesis empirically, we analyzed data from two groups of single-nucleotide polymorphisms (SNPs) that have shown reproducible (n = 9) or reported (n = 39) associations with common diseases. We compared the frequency differentiation (between Europeans and A ...[more]