Ontology highlight
ABSTRACT:
SUBMITTER: Schumacher J
PROVIDER: S-EPMC1380223 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
Schumacher Johannes J Anthoni Heidi H Dahdouh Faten F König Inke R IR Hillmer Axel M AM Kluck Nadine N Manthey Malou M Plume Ellen E Warnke Andreas A Remschmidt Helmut H Hülsmann Jutta J Cichon Sven S Lindgren Cecilia M CM Propping Peter P Zucchelli Marco M Ziegler Andreas A Peyrard-Janvid Myriam M Schulte-Körne Gerd G Nöthen Markus M MM Kere Juha J
American journal of human genetics 20051117 1
We searched for linkage disequilibrium (LD) in 137 triads with dyslexia, using markers that span the most-replicated dyslexia susceptibility region on 6p21-p22, and found association between the disease and markers within the VMP/DCDC2/KAAG1 locus. Detailed refinement of the LD region, involving sequencing and genotyping of additional markers, showed significant association within DCDC2 in single-marker and haplotype analyses. The association appeared to be strongest in severely affected patient ...[more]