Ontology highlight
ABSTRACT:
SUBMITTER: Lauvrak SU
PROVIDER: S-EPMC1382301 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Lauvrak Silje Ugland SU Wälchli Sébastien S Iversen Tore-Geir TG Slagsvold Hege Holte HH Torgersen Maria Lyngaas ML Spilsberg Bjørn B Sandvig Kirsten K
Molecular biology of the cell 20051221 3
Shiga toxin (Stx) is composed of an A-moiety that inhibits protein synthesis after translocation into the cytosol, and a B-moiety that binds to Gb3 at the cell surface and mediates endocytosis of the toxin. After endocytosis, Stx is transported retrogradely to the endoplasmic reticulum, and then the A-fragment enters the cytosol. In this study, we have investigated whether toxin-induced signaling is involved in its entry. Stx was found to activate Syk and induce rapid tyrosine phosphorylation of ...[more]