Ontology highlight
ABSTRACT:
SUBMITTER: Chen JC
PROVIDER: S-EPMC1383518 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
Chen Joseph C JC Hottes Alison K AK McAdams Harley H HH McGrath Patrick T PT Viollier Patrick H PH Shapiro Lucy L
The EMBO journal 20060105 2
We demonstrate that successive cleavage events involving regulated intramembrane proteolysis (Rip) occur as a function of time during the Caulobacter cell cycle. The proteolytic substrate PodJ(L) is a polar factor that recruits proteins required for polar organelle biogenesis to the correct cell pole at a defined time in the cell cycle. We have identified a periplasmic protease (PerP) that initiates the proteolytic sequence by truncating PodJ(L) to a form with altered activity (PodJ(S)). Express ...[more]