Ontology highlight
ABSTRACT:
SUBMITTER: Ohkawa Y
PROVIDER: S-EPMC1383528 | biostudies-literature | 2006 Feb
REPOSITORIES: biostudies-literature
Ohkawa Yasuyuki Y Marfella Concetta G A CG Imbalzano Anthony N AN
The EMBO journal 20060119 3
Myogenin is required not for the initiation of myogenesis but instead for skeletal muscle formation through poorly understood mechanisms. We demonstrate in cultured cells and, for the first time, in embryonic tissue, that myogenic late genes that specify the skeletal muscle phenotype are bound by MyoD prior to the initiation of gene expression. At the onset of muscle specification, a transition from MyoD to myogenin occurred at late gene loci, concomitant with loss of HDAC2, the appearance of bo ...[more]