A novel ubiquitin-binding protein ZNF216 functioning in muscle atrophy.
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ABSTRACT:
SUBMITTER: Hishiya A
PROVIDER: S-EPMC1383529 | biostudies-literature | 2006 Feb
REPOSITORIES: biostudies-literature
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A novel ubiquitin-binding protein ZNF216 functioning in muscle atrophy.
Hishiya Akinori A Iemura Shun-ichiro S Natsume Tohru T Takayama Shinichi S Ikeda Kyoji K Watanabe Ken K
The EMBO journal 20060119 3
The ubiquitin-proteasome system (UPS) is critical for specific degradation of cellular proteins and plays a pivotal role on protein breakdown in muscle atrophy. Here, we show that ZNF216 directly binds polyubiquitin chains through its N-terminal A20-type zinc-finger domain and associates with the 26S proteasome. ZNF216 was colocalized with the aggresome, which contains ubiquitinylated proteins and other UPS components. Expression of Znf216 was increased in both denervation- and fasting-induced m ...[more]
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