Ontology highlight
ABSTRACT:
SUBMITTER: Kharkovets T
PROVIDER: S-EPMC1383535 | biostudies-literature | 2006 Feb
REPOSITORIES: biostudies-literature
Kharkovets Tatjana T Dedek Karin K Maier Hannes H Schweizer Michaela M Khimich Darina D Nouvian Régis R Vardanyan Vitya V Leuwer Rudolf R Moser Tobias T Jentsch Thomas J TJ
The EMBO journal 20060126 3
KCNQ4 is an M-type K+ channel expressed in sensory hair cells of the inner ear and in the central auditory pathway. KCNQ4 mutations underlie human DFNA2 dominant progressive hearing loss. We now generated mice in which the KCNQ4 gene was disrupted or carried a dominant negative DFNA2 mutation. Although KCNQ4 is strongly expressed in vestibular hair cells, vestibular function appeared normal. Auditory function was only slightly impaired initially. It then declined over several weeks in Kcnq4-/- m ...[more]