Ontology highlight
ABSTRACT:
SUBMITTER: Berthiau AS
PROVIDER: S-EPMC1383556 | biostudies-literature | 2006 Feb
REPOSITORIES: biostudies-literature
Berthiau Anne-Sophie AS Yankulov Krassimir K Bah Amadou A Revardel Emmanuelle E Luciano Pierre P Wellinger Raymund J RJ Géli Vincent V Gilson Eric E
The EMBO journal 20060209 4
The Tbf1 and Reb1 proteins are present in yeast subtelomeric regions. We establish in this work that they inhibit telomerase-dependent lengthening of telomere. For example, tethering the N-terminal domain of Tbf1 and Reb1 in a subtelomeric region shortens that telomere proportionally to the number of domains bound. We further identified a 90 amino-acid long sequence within the N-terminal domain of Tbf1 that is necessary but not sufficient for its length regulation properties. The role of the sub ...[more]