Ontology highlight
ABSTRACT:
SUBMITTER: Letourneux C
PROVIDER: S-EPMC1383561 | biostudies-literature | 2006 Feb
REPOSITORIES: biostudies-literature
Letourneux Claire C Rocher Géraldine G Porteu Françoise F
The EMBO journal 20060202 4
The protein phosphatase 2A (PP2A) acts on several kinases in the extracellular signal-regulated kinase (ERK) signaling pathway but whether a specific holoenzyme dephosphorylates ERK and whether this activity is controlled during mitogenic stimulation is unknown. By using both RNA interference and overexpression of PP2A B regulatory subunits, we show that B56, but not B, family members of PP2A increase ERK dephosphorylation, without affecting its activation by MEK. Induction of the early gene pro ...[more]