Ontology highlight
ABSTRACT:
SUBMITTER: Lenasi T
PROVIDER: S-EPMC1383587 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Lenasi Tina T Peterlin B Matija BM Dovc Peter P
RNA (New York, N.Y.) 20060123 3
The complexity of cotranscriptional splicing is reflected in the coordinated interplay between various cis-elements and transacting factors. In this report, we demonstrated that a cis-element in intron 1 of the equine beta-casein gene (intronic splicing enhancer 1, ISE1) increases the inclusion of all weak exons in its pre-mRNA. The ISE1 also functioned on a hybrid transcript, which was transcribed from the alpha-globin promoter, where it increased the inclusion of the human fibronectin EDA exon ...[more]