Ontology highlight
ABSTRACT:
SUBMITTER: Marlovits TC
PROVIDER: S-EPMC138596 | biostudies-literature | 2002 Dec
REPOSITORIES: biostudies-literature
Marlovits Thomas C TC Haase Winfried W Herrmann Christian C Aller Stephen G SG Unger Vinzenz M VM
Proceedings of the National Academy of Sciences of the United States of America 20021122 25
G proteins are critical for the regulation of membrane protein function and signal transduction. Nevertheless, coupling between G proteins and membrane proteins with multiple membrane-spanning domains has so far been observed only in higher organisms. Here we show that the polytopic membrane protein FeoB, which is essential for Fe(II) uptake in bacteria, contains a guanine-nucleotide-specific nucleotide binding site. We identify the G4-motif, NXXD, responsible for guanine nucleotide specificity, ...[more]