Ontology highlight
ABSTRACT:
SUBMITTER: Wang T
PROVIDER: S-EPMC138636 | biostudies-literature | 2002 Dec
REPOSITORIES: biostudies-literature
Molecular biology of the cell 20021201 12
We present evidence to suggest the existence of a regulatory pathway for the Golgi apparatus to modulate the spatial positioning of otherwise distantly located lysosomes. Rab34, a new member of the Rab GTPase family, is associated primarily with the Golgi apparatus. Expression of wild-type or GTP-restricted but not GDP-restricted versions of Rab34 causes spatial redistribution of lysosomes from the periphery to the peri-Golgi region. The regulation of lysosomal positioning by Rab34 depends on it ...[more]