Ontology highlight
ABSTRACT:
SUBMITTER: Boden M
PROVIDER: S-EPMC1386714 | biostudies-literature | 2006
REPOSITORIES: biostudies-literature
Bodén Mikael M Yuan Zheng Z Bailey Timothy L TL
BMC bioinformatics 20060214
<h4>Background</h4>The structure of proteins may change as a result of the inherent flexibility of some protein regions. We develop and explore probabilistic machine learning methods for predicting a continuum secondary structure, i.e. assigning probabilities to the conformational states of a residue. We train our methods using data derived from high-quality NMR models.<h4>Results</h4>Several probabilistic models not only successfully estimate the continuum secondary structure, but also provide ...[more]