Ontology highlight
ABSTRACT:
SUBMITTER: Seebohm G
PROVIDER: S-EPMC1386802 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Seebohm Guiscard G Strutz-Seebohm Nathalie N Ureche Oana N ON Baltaev Ravshan R Lampert Angelika A Kornichuk Ganna G Kamiya Kaichiro K Wuttke Thomas V TV Lerche Holger H Sanguinetti Michael C MC Lang Florian F
Biophysical journal 20051202 6
Voltage-gated K+ channel activation is proposed to result from simultaneous bending of all S6 segments away from the central axis, enlarging the aperture of the pore sufficiently to permit diffusion of K+ into the water-filled central cavity. The hinge position for the bending motion of each S6 segment is proposed to be a Gly residue and/or a Pro-Val-Pro motif in Kv1-Kv4 channels. The KCNQ1 (Kv7.1) channel has Ala-336 in the Gly-hinge position and Pro-Ala-Gly. Here we show that mutation of Ala-3 ...[more]