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An overview of the structures of protein-DNA complexes.


ABSTRACT: On the basis of a structural analysis of 240 protein-DNA complexes contained in the Protein Data Bank (PDB), we have classified the DNA-binding proteins involved into eight different structural/functional groups, which are further classified into 54 structural families. Here we present this classification and review the functions, structures and binding interactions of these protein-DNA complexes.

SUBMITTER: Luscombe NM 

PROVIDER: S-EPMC138832 | biostudies-literature | 2000

REPOSITORIES: biostudies-literature

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An overview of the structures of protein-DNA complexes.

Luscombe N M NM   Austin S E SE   Berman H M HM   Thornton J M JM  

Genome biology 20000609 1


On the basis of a structural analysis of 240 protein-DNA complexes contained in the Protein Data Bank (PDB), we have classified the DNA-binding proteins involved into eight different structural/functional groups, which are further classified into 54 structural families. Here we present this classification and review the functions, structures and binding interactions of these protein-DNA complexes. ...[more]

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