Ontology highlight
ABSTRACT:
SUBMITTER: Chen JC
PROVIDER: S-EPMC139535 | biostudies-literature | 2002 Feb
REPOSITORIES: biostudies-literature
Chen Joseph C JC Minev Michael M Beckwith Jon J
Journal of bacteriology 20020201 3
FtsQ, a 276-amino-acid, bitopic membrane protein, is one of the nine proteins known to be essential for cell division in gram-negative bacterium Escherichia coli. To define residues in FtsQ critical for function, we performed random mutagenesis on the ftsQ gene and identified four alleles (ftsQ2, ftsQ6, ftsQ15, and ftsQ65) that fail to complement the ftsQ1(Ts) mutation at the restrictive temperature. Two of the mutant proteins, FtsQ6 and FtsQ15, are functional at lower temperatures but are unabl ...[more]