Ontology highlight
ABSTRACT:
SUBMITTER: Bowman BR
PROVIDER: S-EPMC1395411 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Bowman Brian R BR Welschhans Robert L RL Jayaram Hariharan H Stow Nigel D ND Preston Valerie G VG Quiocho Florante A FA
Journal of virology 20060301 5
Herpesviruses replicate their double stranded DNA genomes as high-molecular-weight concatemers which are subsequently cleaved into unit-length genomes by a complex mechanism that is tightly coupled to DNA insertion into a preformed capsid structure, the procapsid. The herpes simplex virus type 1 UL25 protein is incorporated into the capsid during DNA packaging, and previous studies of a null mutant have demonstrated that its function is essential at the late stages of the head-filling process, e ...[more]