Ontology highlight
ABSTRACT:
SUBMITTER: Pocai A
PROVIDER: S-EPMC1395479 | biostudies-literature | 2006 Apr
REPOSITORIES: biostudies-literature
Pocai Alessandro A Lam Tony K T TK Obici Silvana S Gutierrez-Juarez Roger R Muse Evan D ED Arduini Arduino A Rossetti Luciano L
The Journal of clinical investigation 20060309 4
Short-term overfeeding blunts the central effects of fatty acids on food intake and glucose production. This acquired defect in nutrient sensing could contribute to the rapid onset of hyperphagia and insulin resistance in this model. Here we examined whether central inhibition of lipid oxidation is sufficient to restore the hypothalamic levels of long-chain fatty acyl-CoAs (LCFA-CoAs) and to normalize food intake and glucose homeostasis in overfed rats. To this end, we targeted the liver isoform ...[more]