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Efficient synthesis of 5-substituted 2-aryl-6-cyanoindolizines via nucleophilic substitution reactions.

ABSTRACT: 2-Aryl-6-cyano-7-methyl-5-indolizinones were successfully converted into 2-aryl-5-chloro-6-cyano-7-methylindolizines. The obtained 5-chloroindolizines readily underwent nucleophilic substitution at position 5 leading in high yields to novel 5-functionalised indolizines.

SUBMITTER: Babaev EV

PROVIDER: S-EPMC1399457 | biostudies-literature | 2005 Oct

REPOSITORIES: biostudies-literature

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Efficient synthesis of 5-substituted 2-aryl-6-cyanoindolizines via nucleophilic substitution reactions.

Babaev Eugene V EV Vasilevich Natalya I NI Ivushkina Anna S AS

Beilstein journal of organic chemistry 20051007 1

2-Aryl-6-cyano-7-methyl-5-indolizinones were successfully converted into 2-aryl-5-chloro-6-cyano-7-methylindolizines. The obtained 5-chloroindolizines readily underwent nucleophilic substitution at position 5 leading in high yields to novel 5-functionalised indolizines. ...[more]

PMID: 16542026

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