Finding weak similarities between proteins by sequence profile comparison.
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ABSTRACT:
SUBMITTER: Panchenko AR
PROVIDER: S-EPMC140518 | biostudies-literature | 2003 Jan
REPOSITORIES: biostudies-literature
Publications
Finding weak similarities between proteins by sequence profile comparison.
Nucleic acids research 20030101 2
To improve the recognition of weak similarities between proteins a method of aligning two sequence profiles is proposed. It is shown that exploring the sequence space in the vicinity of the sequence with unknown properties significantly improves the performance of sequence alignment methods. Consistent with the previous observations the recognition sensitivity and alignment accuracy obtained by a profile-profile alignment method can be as much as 30% higher compared to the sequence-profile align ...[more]
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