Ontology highlight
ABSTRACT:
SUBMITTER: Bashirova AA
PROVIDER: S-EPMC140574 | biostudies-literature | 2003 Jan
REPOSITORIES: biostudies-literature
Bashirova Arman A AA Wu Li L Cheng Jie J Martin Thomas D TD Martin Maureen P MP Benveniste Raoul E RE Lifson Jeffrey D JD KewalRamani Vineet N VN Hughes Austin A Carrington Mary M
Journal of virology 20030101 1
Two CD209 family genes identified in humans, CD209 (DC-SIGN) and CD209L (DC-SIGNR/L-SIGN), encode C-type lectins that serve as adhesion receptors for ICAM-2 and ICAM-3 and participate in the transmission of human and simian immunodeficiency viruses (HIV and SIV, respectively) to target cells in vitro. Here we characterize the CD209 gene family in nonhuman primates and show that recent evolutionary alterations have occurred in this family across primate species. All of the primate species tested, ...[more]